Vitamin D levels and the effectiveness of a calcium supplement in treatment of osteoporosis in postmenopausal women

Objective. Assessment of vitamin D levels and the clinical effectiveness of treatment of postmenopausal osteoporosis with the use of a combined supplement containing calcium carbonate in the dose 2500 mg and cholecalciferol 800 IU.
Patients and methods. The study included 48 postmenopausal women. Patients with osteoporosis (n = 25) received an oral combined supplement containing calcium carbonate 2500 mg and cholecalciferol 800 IU once daily. The control group consisted of 23 postmenopausal women who had no impairment of bone metabolism and did not receive any therapy for osteoporosis.
Results. Patients of the treatment group had a statistically significant decrease of the levels of bone mineral density (BMD) and vitamin D concentrations as compared to the corresponding parameters in the control group. After the termination of the course of therapy, patients of the treatment group had a tendency to improvement of BMD parameters as compared to the values before treatment, though no significant differences with the initial levels were obtained. Assessment of the b-CrossLaps concentrations was also indicative of the absence of any significant effect of the supplementation on the degree of bone resorption. 
Conclusion. Treatment of postmenopausal osteoporosis should include management of vitamin D deficiency taking into account its initial levels, which would permit to enhance the effectiveness of calcium supplementation.
Key words: postmenopausal osteoporosis, vitamin D, bone fractures, calcium supplements, hormone replacement therapy.
For citation: Smykalova A.S., Zhilenko M.I. Vitamin D levels and the effectiveness of a calcium supplement in treatment of osteoporosis in postmenopausal women. Vopr. dietol. (Nutrition). 2019; 9(3): 44–49. (In Russian).
DOI: 10.20953/2224-5448-2019-3-44-49


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