Analysis of the prevalence of omega-3 polyunsaturated fatty acid deficiency among the female and male population of the Moscow region
Patients and methods. We analysed measurements of the omega-3 index in 1349 patients aged 1 to 91 years, not receiving omega-3 PUFA preparations, who presented with various complaints in the period 2013–2017. The omega-3 index is an important marker of metabolism reflecting the percentage of eicosapentaenoic and docosahexaenoic acids to the total amount of all fatty acids in red blood cell membranes. The omega-3 index was determined by the method of gas chromatography – mass spectrometry. Fatty acids within red cell membranes were analysed by the related methyl esters after transesterification by sodium methylate.
Results. Deficiency of omega-3 PUFAs was found in 68.5% of patients. The most severe deficiency was noted in children and adolescents aged 0 to 17 years (in girls to a greater extent). In age groups of 18–44 and 45–59 years, the prevalence of severe (<4%) and moderate (4–8%) deficiency was comparable in males and females: among 18–44-year-old men severe deficiency was noted in 5.6%, moderate – in 29.4%, at the age of 45–59 years – in 7 and 23%, respectively; among women – 6.4, 24.4, 8.4 and 20%, respectively. In the age group of 60-74 years, prevalence of severe deficiency was significantly higher in men, who had severe deficiency in 9.2% of cases, whereas in women of the same age it was found only in 4.8% of cases, the prevalence of moderate deficiency is 23 and 23.8%, respectively.
Conclusion. The obtained data are indicative of the necessity to choose dosages of omega-3 PUFA preparations, taking into account not only age, but also gender of patients as well.
Key words: deficiency, omega-3 PUFAs, omega-3 index, prevalence.
For citation: Kalinchenko S.Yu., Vorslov L.O., Avetisyan L.A., Belov D.A., Paramonov S.A., Nizhnik A.N., Davidyan O.V. Analysis of the prevalence of omega-3 polyunsaturated fatty acid deficiency among the female and male population of the Moscow region. Vopr. dietol. (Nutrition). 2018; 8(2): 10–15. (In Russian).