Sarcopenia: will only protein nutrition and physical activity help? The role of sex steroid hormones in the mechanisms of synthesis of muscle protein regulation

Sarcopenia is a syndrome characterized by progressive loss of mass and strength of skeletal muscles, which is associated with a high risk of adverse outcomes (disability, poor quality of life and death), initiation and progression of many age-associated diseases. The role of the anatomical and functional state of skeletal muscles in maintaining health and increasing the duration of the active phase of life has remained underestimated for many years, but recently the attitude towards sarcopenia has changed dramatically, which is connected both with the understanding of the need for its correction to ensure the quality of life of an aging person, In connection with a more detailed study of the pathogenesis of sarcopenia. In this article, the pathogenetic mechanisms of sarcopenia and, above all, the role of sex steroid hormones in the mechanisms of the regulation of the synthesis of muscle proteins are considered to a greater degree. The extensive clinical and experimental material accumulated in recent years makes it possible to conclude that one of the key roles of sex steroid hormones (testosterone and DHEA (S) in both sexes and progesterone in women) is in providing adequate metabolism of muscle tissue, which determines the potential positive pathogenetic effects of replacement therapy with these hormones with respect to age-related sarcopenia in men and women.

Key words: sarcopenia, aetiology, pathogenesis, sex steroid hormones, testosterone, progesterone, DHEA (S).

For citation: Tyuzikov I.A., Kalinchenko S.Yu. Sarcopenia: will only protein nutrition and physical activity help? The role of sex steroid hormones in the mechanisms of synthesis of muscle protein regulation. Vopr. dietol. (Nutrition). 2017; 7(2): 41–50. (In Russian).
DOI: 10.20953/2224-5448-2017-2-41-50

Яндекс.Метрика