The review article examines the pathogenetic relationships between the current medical and social problems of modern medicine: sleep disorders caused by melatonin deficiency, obesity and insulin resistance, which are rightly called the «new world pandemics» of the 21st century. In the human body there is a whole endocrine system of melatonin, consisting of epiphyseal (central) and tissue (peripheral) melatonin, the physiological functions of which seem extremely diverse. There are several melatonin products in Russian market, including high-quality melatonin product Sonnovan manufactured in Russia by Canonpharma production company. Being not only a key regulator of the sleep-wake system, but also a powerful natural antioxidant, fat-burning hormone with a pronounced positive effect on carbohydrate metabolism, melatonin takes an active part in fat, carbohydrate, energy metabolism and muscle metabolism, which predetermines the development of obesity and insulin resistance in response to any deficiency in the synthesis and / or secretion of this hormone. The article considers brief endocrinology of melatonin, methods for diagnosing its deficiency, as well as possible pathogenetic mechanisms of obesity and insulin resistance, caused by melatonin deprivation.
melatonin, melatonin deficiency, diagnostics, oxidative stress, obesity, sarcopenic obesity, insulin resistance, pathogenetic interactions.
Kalinchenko S.Yu., Tyuzikov I.A. Deficiency of melatonin, obesity and insulin resistance: obvious and non-obvious interrelations. Vopr. dietol. (Nutrition). 2017; 7(2): 23–32. (In Russian).