Specificities of complex nutritive support of patients with cytostatic therapy and haemopoietic stem cell transplantation

Introduction. Haemopoietic stem cell transplantation (HSCT) is a radical method of treatment of oncological, haematological and hereditary diseases, but it is associated with a great number of complications among which there is malnutrition that decreases the effect of treatment.

Objective. To assess the effectiveness of enteral feeding in patients with HSCT. 

Patients and methods. We analysed 268 cases when patients were treated by various kinds of cytostatic therapy and HSCT. Their age varied from 4 months to 77 years. 222 patients received HSCT; 40 – chemotherapy; 6 – immunotherapy. Anthropometry and biochemical markers were used for assessment of nutritional status.

Results. The main syndromes at physician visits were: underweight, anorexia, intestinal dyspepsia and malabsorption. For correction of malnutrition first-line therapy was given: low-microbial diet (n = 92), sipping (n = 132), enteral feeding (n = 10), parenteral feeding (n = 34). In 64.9% of cases, first-line nutritive support (NS) was not effective. Second-line therapy (n = 69) with inclusion of appetite stimulants, semi-elemental formulas for sipping have shown a greater effectiveness.

Conclusion. Patients with HSCT are a high risk group for development of malnutrition and have low tolerance to standard preparations for enteral feeding. A higher effectiveness of NS was noted when using semi-elemental formulas in combination with appetite stimulants and enzymes.

Key words: sipping, haemopoietic stem cell transplantation, enteral feeding.

For citation: Kucher M.A., Pirogova O.V., Goloshchapov O.V., Karev V.E., Shvetsov A.N., Afanas’ev B.V. Specificities of complex nutritive support of patients with cytostatic therapy and haemopoietic stem cell transplantation.Vopr. dietol. (Nutrition). 2016; 6(1): 5–12.

DOI: 10.20953/2224-5448-2016-1-5-12

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