Infectious Diseases

A clinical-laboratory characteristic of coronavirus infection in children

The objective. To offer a clinical and laboratory characteristic of coronavirus infection in hospitalised children.

Patients and methods. The group of study included 50 children, who were diagnosed with coronavirus infection by polymerase chain reaction (PCR). Mono-coronavirus infection was found in 40 children (80%), mixed virus infection conditioned by a combination of two or three viruses – in 10 children (20%).

Results. In all examined children with coronavirus infection disease had an acute onset and took a mild or moderate course. In general, the clinical picture of disease was manifested by cough, signs of rhinitis (stuffy nose, mucus discharge from the nose), febrile fever (in 52.5% of patients with mono-infection and in 80% of children with mixed infection), laryngotracheitis with laryngeal stenosis grade 1 (in 52.5% with mono-infection and in 80% with mixed infection). In 10% of children with monoinfection and in 50% of children with mixed infection gastrointestinal dysfunction was noted in the form of repeated vomiting to 2–6 times, diarrhoea to 1–4 times daily without pathological admixtures. Haematological parameters did not show any characteristic specificities in any child in both mono-infection and mixed infection.

Conclusion. Catarrhal inflammation is the leading clinical syndrome in mono- and mixed coronavirus infection; disease was manifested by cough, often – elevated body temperature, signs of stenosing laryngitis; part of children developed gastrointestinal dysfunction.

Key words: children, clinical and laboratory specificities, coronavirus infection, acute respiratory infections (ARIs).

For citation: Nikolaeva S.V., Zvereva Z.A., Kanner E.V., Yatsyshina S.B., Usenko D.V., Gorelov A.V. A clinical-laboratory characteristic of coronavirus infection in children. Infekc. bolezni (Infectious diseases). 2018; 16(1): 35–39. (In Russian).
DOI: 10.20953/1729-9225-2018-1-35-39