Acute cytomegalovirus infection in adult HIV-negative patients
The objective. To study the clinical specificities and to evaluate the efficacy of administered antiviral therapy for acute acquired manifested cytomegalovirus infection in adult HIV-negative patients. Patients and methods. The clinical course of disease was analyzed in 61 patients with acute acquired manifested cytomegalovirus infection confirmed by serological tests and polymerase chain reaction. Results. As has been shown, the most common clinical sign of acute acquired manifested cytomegalovirus infection is a higher body temperature and other symptoms of intoxication, hepatomegaly with hepatic enzyme induction, splenomegaly, affection of the respiratory tract and palpable lymph nodes. Conclusion. A specificity of the clinical form of acute cytomegalovirus infection is its frequent combination with infection associated with Epstein-Barr virus. Antiviral drug therapy results in normalization of temperature, coping with affection of the organs and improvement of patients’ condition.