Acute cytomegalovirus infection in adult HIV-negative patients

Authors / Institutions

Zhukova L.I. / Kuban State Medical University, Ministry of Public Health and Social Development of the Russian Federation, Krasnodar

Lebedev V.V. / Pediatric Territorial Clinical Hospital, Krasnodar, the Russian Federation

V.N.Gorodin / Kuban State Medical University, Krasnodar, the Russian Federation

Zotov S.V. / Specialized Clinical Infectious Hospital, Ministry of Public health of the Krasnodar Region, Krasnodar, Russian Federation

Kovalevskaya O.I. / Specialized Clinical Infectious Hospital of the Krasnodar Region (SCIH), Krasnodar

Chakhoyan P.O. / Kuban State Medical University, Krasnodar

The objective. To study the clinical specificities and to evaluate the efficacy of administered antiviral therapy for acute acquired manifested cytomegalovirus infection in adult HIV-negative patients. Patients  and  methods.  The  clinical  course  of  disease  was  analyzed  in  61  patients  with  acute  acquired  manifested cytomegalovirus infection confirmed by serological tests and polymerase chain reaction. Results. As has been shown, the most common clinical sign of acute acquired manifested cytomegalovirus infection is a higher body temperature and other symptoms of intoxication, hepatomegaly with hepatic enzyme induction, splenomegaly, affection of the respiratory tract and palpable lymph nodes. Conclusion.  A  specificity  of  the  clinical  form  of  acute  cytomegalovirus  infection  is  its  frequent  combination  with  infection associated with Epstein-Barr virus. Antiviral drug therapy results in normalization of temperature, coping with affection of the organs and improvement of patients’ condition.