Functional liver disorders in patients with acute moderate gastroenterites
The objective. To establish the presence and character of liver disorders in patients with acute moderate gastroenterites. Patients and methods. 170 patients with acute moderate infectious gastroenterites were examined (age 38.0 ± 1.4 years, females 57.7%). Al the patients had dynamic biochemical examination, part of the patients underwent tetrapolar rheohepatography, ultrasound scanning, detection of blood nitric oxide, interleukin-10 and interleukin-12 levels. Results. Clinical symptoms of liver damage were found in 31.8% of patients, biochemical symptoms – in 71.4%, their incidence did not depend on the etiology of gastroenteritis or presence of associated diseases diagnosed in 86.5% of patients according to the findings of ultrasound scanning. Rheographic examination detected the presence of microcirculatory intrahepatic disorders, leading to oedema of the liver and impaired bile outflow. The cytokine dynamics correlated with the severity and frequency of organ disorders, confirmed a systemic character of inflammatory process in acute infectious gastroenterites. Conclusion. In a number of patients with acute moderate gastroenterites, combination of clinical, laboratory and instrumental signs of the liver function disorders were indicative of the possibility of development of the manifestations of hepatitis, which required targeted treatments.