Infectious Diseases

Clinical efficacy of the nonsteriod antiinflammatory drug Nurofen in a complex treatment of patients with erysipelas

The authors made a clinical and laboratory evaluation of the efficacy of the nonsteroid antiinflammatory drug Nurofen (ibuprofen) in a complex therapy of patients with the erythematous and erythematous-bullous forms of erysipelas of moderate severity. A positive effect of the drug was obtained, which was expressed in a faster coping with the signs of intoxication syndrome and laboratory indications of systemic inflammatory reaction (decrease of ESR, leukocytes, antiinflammatory cytokines TNF-? and IL-8) in the absence of an inhibiting effect on production of the antiinflammatory cytokine IL-4 and microbicidal activity of neutrophilic leukocytes.