Gynecology, Obstetrics and Perinatology

Acute fatty liver of pregnancy: clinical and diagnostic controversies, complications and prognosis

A clinical case of a 36-year-old woman, who at the 33 wks of gestation developed a variation of microangiopathy – acute fatty liver, complicated by a subsequent development of destructive pancreatitis. A lethal outcome occurred on the 6th day after preterm delivery due to endogenous intoxication. The article considers the issues of the pathogenesis of acute fatty liver, difficulties of its diagnosis and differential diagnosis of various microangiopathies in pregnant women, including preeclampsia, prognosis of adverse events, and specificities of therapy.

Key words: pregnancy, acute fatty liver of pregnancy, preeclampsia, acute pancreatitis in pregnancy.
For citation: Strizhakov A.N., Ignatko I.V., Timokhina E.V., Dyuzheva T.G., Afanasyeva N.V., Golubenko E.O., Dudina I.A., Matsneva I.A. Acute fatty liver of pregnancy: clinical and diagnostic controversies, complications and prognosis. Вопросы гинекологии, акушерства и перинатологии. 2019; 18(3): 133–139. (In Russian).
DOI: 10.20953/1726-1678-2019-3-133-139