Gynecology, Obstetrics and Perinatology

The effect of oxytocin dosage on the amount of intraoperative blood loss during caesarean section

The objective: a comparative study of the effects of oxytocin dosage on blood loss during caesarean section (CS) under spinal anaesthesia in somatically healthy young primiparas and primiparas of optimal reproductive age.

Patients and methods. A prospective randomised study of 44 primiparas aged 15 to 25 years, who underwent planned caesarean section under spinal anaesthesia was performed. The amount of intraoperative blood loss was determined indirectly. A randomization algorithm included distribution of patients to 2 groups by random-number generation and was performed by the method of sealed envelopes. Δ haemoglobin was calculated as a difference between the results before and after CS. 

Results. The average blood loss in the group of patients who received oxytocin 5 IU was 600.0 (115.5) ml, in the group of patients who received oxytocin 10 IU, blood loss was 672.7 (132.5) ml (p = 0.059). The average Δ haemoglobin value was 12.1 (1.6) and 20 (1.7) g/l, respectively, р < 0.0001.

Conclusion. Injection of oxytocin 10 IU during CS increases the amount of blood loss by more than 12% as compared with the 5 IU dose.

Key words: caesarean section, blood loss, oxytocin, spinal anaesthesia.
For citation: Degtyaryev E.N., Shifman E.M., Tikhova G.P., Kulikov А.V., Zhukovets I.V. The effect of oxytocin dosage on the amount of intraoperative blood loss during caesarean section. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2018; 17(6): 51–56. (In Russian).
DOI: 10.20953/1726-1678-2018-6-51-56