Oxytocin as a risk factor for developing myocardial ischemia

Authors / Institutions

E.N.Degtyaryev / Amur Regional Clinical Hospital, Blagoveshchensk, Russian Federation

Efim M. Shifman / M.F.Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russian Federation

Galina P. Tikhova / Petrozavodsk State University, Petrozavodsk, Russian Federation

Aleksandr V. Kulikov / Urals State Medical University, Ekaterinburg, Russian Federation

A.A.Bukhtin / L.I.Ushakova Volgograd Regional Clinical Perinatal Centre No 1, Volzhsky, Russian Federation

Irina V. Zhukovets / Amur State Medical Academy, Blagoveshchensk, Russian Federation / Scientific Center for Family Health and Human Reproduction Problems, Siberian Branch of Russian Academy of Medical Sciences, Irkutsk, Russian Federation

The objective. To study the effect of oxytocin (OT) dose on ST segment depression during caesarean section under spinal anaesthesia in somatically healthy young primiparas and primiparas of optimal reproductive age.

Patients and methods. A prospective randomized study of ST segment depression after introduction of OT in 45 14-25-yearold
patients giving birth for the first time. Analysis of ST-segment was performed using the Mindray BeneView T6 patient monitor
(China).

Results. In the joint group of patients, where OT was introduced in the dose 10 U, chances for developing acute ischemia were
by 36 times higher as compared with the group where OT dose was 5 U. Among the young primiparas, chances of developing
myocardial ischemia were by 45 times higher in introduction of OT in the dose 10 U as compared with the dose of 5 U. But among adult patients, chances of developing myocardial ischemia were by 30 times higher in introduction of OT in the dose 10 U as compared with the dose 5 U.

Conclusion. Development of myocardial ischemia is in direct relationship with the dose of introduced OT during caesarean
section.

Key words: myocardial ischemia, oxytocin, young primiparas.

For citation: Degtyaryev Ye.N., Shifman Ye.M., Tikhova G.P., Kulikov А.V., Bukhtin А.А., Zhukovets I.V. Oxytocin as a risk factor for developing myocardial ischemia. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2018; 17(4): 5–10. (In Russian).
DOI: 10.20953/1726-1678-2018-4-5-10