Gynecology, Obstetrics and Perinatology

Prevention of loss of pregnancy after IVF in patients with low ovarian reserve

The objective. To establish specificities of the course of a singleton pregnancy occurring after the use of assisted reproductive technologies (ART) and the frequency of its loss in patients with low ovarian reserve in the 1st trimester of gestation.

Patients and methods. The study included 151 pregnant women. Depending on ovarian reserve, two groups were singled out. Results. The incidence of complications in the 1st trimester was greater in the group of patients with low ovarian reserve – 88 (79.3%). Complications occurred by 1.7 times less frequently in case of the tuboperitoneal factor (p < 0.05). In group 1, pregnancy loss was noted in 20 (18.01%), in the structure of pregnancy loss there were 2 cases of anembryonic pregnancy (9.5%), 9 patients (42.8%) had incomplete miscarriage, 10 (47.6%) had undeveloped pregnancy. In group 2, pregnancy was lost only in 4 cases (10%) (p > 0.05).

Conclusion. The age after 37 years in combination with anti-Mueller hormone levels (AMH) lower than 0.4 ng/ml are prognostic factors for the development of pregnancy complications and loss in the 1st trimester.

Key words: IVF pregnancy, infertility, complications of IVF pregnancy, pregnancy loss, low ovarian reserve.

For citation: Rabadanova A.K., Shalina R.I., Gugushvili N.A., Gavrilina E.N., Denisenko M.V. Prevention of loss of pregnancy after in vitro fertilisation in patients with low ovarian reserve. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2017; 16(6): 36–43. (In Russian).
DOI: 10.20953/1726-1678-2017-6-36-43