Gynecology, Obstetrics and Perinatology

A comparative characteristic of perinatal outcomes in women of late reproductive age after IVF with own and donor oocytes

The objective. Assessment of the influence of IVF with own and donor eggs on maternal and perinatal outcomes in women who give birth after the age of 40.

Patients and methods. We analysed the course of pregnancies, labour and perinatal outcomes in 359 women aged 40 years and more. In 153 women pregnancy occurred after IVF with the use of donor eggs (IVF-DE), in 103 women after IVF with own eggs (IVF-OE) and in 103 women pregnancy occurred spontaneously (SP).

Results. Recipients of donor oocytes had a higher risk of development of obstetric complications than pregnant women after IVF with the use of own oocytes and women with spontaneously occurring pregnancy. In the IVF-DE group, a higher incidence of preterm births (30.7%), gestational arterial hypertension (32.0%), preeclampsia (26.1%), premature placental abruption (4.6%), hypotonic haemorrhage (5.2%) were noted.

Conclusion. In women aged 40 years and older, pregnancy resulting from IVF with the use of donor eggs is associated with higher risks of obstetric complications than in women with spontaneously occurring pregnancy or after IVF with own eggs.

Key words: gestational arterial hypertension, oocyte donation, preterm delivery, preeclampsia, IVF.

For citation: Trifonova N.S., Zhukova E.V., Aleksandrov L.S., Grinyova A.M., Ishchenko A.I., Borisova N.I., Soboleva V.V. A comparative characteristic of perinatal outcomes in women of late reproductive age after IVF with own and donor oocytes. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2017; 16(6): 5–10. (In Russian).
DOI: 10.20953/1726-1678-2017-6-5-10