Gynecology, Obstetrics and Perinatology

Perinatal outcomes in premature birth

The objective. Тo assess perinatal outcomes in premature birth at different terms of pregnancy.

Patients and methods. A retrospective study of 382 histories of single-fetus pregnancy terminated by premature births.

Results. Most premature births (45.3%) occurred at terms 34–37 wks of gestation. The incidence of very early premature births (before 28 wks) was 9.69%, early premature births (28–30 wks and 6 days) – 20.94%, premature births (31–33 wks and 6 days) – 23.56%. The main causes of preterm termination of pregnancy were preterm development of regular contractions (34.0%), severe complications of pregnancy (33.5%) and premature rupture of membranes (32.5%). Perinatal mortality in premature birth was 60.21‰, early neonatal losses – 45.21‰. The highest incidence of perinatal losses (69.6%) goes to the term before 28 weeks of gestation. Perinatal mortality of children born at terms before 26 weeks of gestation was 666.7‰, at terms 26-28 wks – 227.3‰, 28–32 weeks of gestation – 37.5‰, 32–35 wks – 33.3‰, 35–37 wks – 5.78‰. The main causes of perinatal deaths were prematurity (30.43%), intraventricular haemorrhages grades 2–4 (21.74%), intrauterine infection (13.04%), foetal malformations (8.7%).
Conclusion. Preterm birth before 28 weeks is the most serious problem, since two thirds of perinatal losses occur at these gestational terms. Prolongation of pregnancy to terms more than 28 weeks permits to improve perinatal outcomes in premature birth. 

Key words: intraventricular haemorrhages, hypoxic-ischaemic lesion of CNS, hypoxia, premature birth, perinatal mortality,
respiratory distress syndrome

For citation: Strizhakov A.N., Belousova V.S., Timokhina E.V., Bogomazova I.M., Pitskhelauri E.G., Podtetenev A.D., Kuznetsova E.V., Tolkach Yu.I. Perinatal outcomes in premature birth. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2016; 15(4): 7–12. DOI: 10.20953/1726-1678-2016-4-7-12