Gynecology, Obstetrics and Perinatology

Clinical significance of studying growth factors and their receptors in predicting pregnancy complications in women with hypertensive disease

The authors performed a prospective analysis of the course of pregnancy and birth outcomes in 110 women who were divided  into 2 groups. Group 1 comprised 30 women with noncomplicated pregnancy, group 2 – 80 pregnant women with hypertensive disease (HD) grade 1 and 2. The study found that in patients with HD and a noncomplicated course of gestation the values of angiogenic growth factors were lower that in physiological pregnancy, however, they did not differ significantly from normative values. In development of gestosis of moderate severity and subcompensated placental insufficiency (PI), the level of VEGF R-1 increased by 2.6 times, IGF-1 and PlGF were reduced by 2.1 and 1.9 times, respectively. In development of severe gestosis and decompensated PI, the values of VEGF R-1 increased by 4 times, IGF-1 and PlGF were reduced by 2.3 and 3.5 times,  respectively. The degree of increase of VEGF R-1 levels in gestosis and PI corresponds to the degree of decrease of PlGF concentrations, which confirms their specific interaction and a high significance of detection of these factors for predicting development of gestosis and PI at the preclinical stage.