Variants of systemic angiogenesis in pregnant women with intrauterine infection of phetus
The authors studied variants of systemic angiogenesis in pregnant women with intrauterine infection (IUI). Baseline clinical characteristic, specificities of the course of pregnancy and labor, the state of fetuses and newborns in 210 women were analyzed. The examined women were referred to the following groups: group 1 (control) – 34 conditionally healthy pregnant women who gave birth to healthy babies- group 2 (basic): subgroup 2A– 81 women at high infection risk who gave birth to babies without signs of IUI, subgroup 2B – 79 women whose newborn babies had mild signs of IUI, subgroup 2C – 16 women whose newborn babies had severe signs of IUI. In all the women whose babies had no signs of IUI in the control group and in group 2А the first variant was observed – typical angiogenesis of mother and fetus. In realization of IUI in subgroup 2B and 2C, the second variant was noted – atypical angiogenesis, namely, combination of insufficient maternal angiogenesis and excessive fetal angiogenesis, which is related to modification of placental and paraplacental angiogenesis.