Gynecology, Obstetrics and Perinatology

Cytomorphological changes in blood of patients with surgical menopause syndrome

An examination of 50 women aged 41.3 ± 1.6 years was carried out prior to surgery and 6 to 12 months after hysterectomy without adnexa (group 1) and with unilateral adnexectomy (group 2). The control group included 25 healthy women. An evaluation of the severity of climacteric disorders was made, specificities of lipid and carbohydrate metabolism, activity of mitochondrial dehydrogenases before surgery, after surgery and after metabolite therapy. In the patients, within the first year after surgery  neurovegetative  and  psychoemotional  disorders  appeared,  their  prevalence  by  groups  was  estimated  to  64.0  and 68%. The metabolic disorders in women with a history of hysterectomy included the body weight gains, changes of carbohydrate and lipid metabolism. An analysis of the functional activity of the mitochondria showed that 33% of women after an operative treatment had deviations in the indices of the leukocyte enzymatic status expressed in an increased activity of the mitochondria to 40% as compared with the upper limit of normal. An increase of total activity occurred at the expense of the presence of a pool of individual especially excited mitochondria on the background of a decreased activity of the mitochondria in clusters. No reliable differences between groups 1 and 2 were noted. After the therapy, all patients had an increased of performance, a decrease of irritability, improvement of sleep, normalization of the indices of lipid and carbohydrate metabolism, improvement of the energy potential of cells.