Gynecology, Obstetrics and Perinatology

Principles of complex therapy of threatened abortion in women with habitual miscarriage

With the aim to evaluate the efficacy of using Magne-B6 in complex therapy of threatened abortion and retrochorial hematoma in pregnant women with habitual miscarriage the authors carried out a complex clinical and laboratory examination of 216 pregnant women (basic group) with a history of habitual miscarriage and with clinical manifestations of threatened abortion at terms from 5 to 13 weeks of gestation. It was shown that the greatest efficacy of using Magne-B6 in complex therapy of threatened abortion was obtained in combination of the following clinical and echographic criteria: complaints of nagging pains in the lower abdomen and back- absence or insignificant bloody discharge from the genital tracts- myometrial tone detected by US- presence of a retrochorial hematoma of small size- isolated decrease of the size of the amniotic cavity- impaired blood flow in spiral arteries (PI ? 0,67) and intervillous space (at terms 8–13 weeks RI &-gt- 0.51 ± 0.06,  PI &-gt- 0.72 ± 0.06). The treatment resulted in a regression of all clinical symptoms within 5-7 days, and on the background of a reliable increase of the size of the ovum an adequate increase of embryometric parameters (CRL) was observed. Simultaneously, the complex therapy contributed to a 1.8-fold decrease of the incidence of spontaneous abortions and early reproductive losses in the group of women with habitual miscarriage. In the reference group, the incidence of spontaneous abortion was 13.3% v. 7.41% in the basic group.