Prevention of reproductive losses in habitual miscarriage
A prospective examination of 188 women with habitual miscarriage was performed. The basic group comprised 126 women with habitual miscarriage in I trimester, who received didrogesterone prophylaxis of reproductive losses at the stage of pregravid preparation and in early pregnancy up to the 20 week of gestation (in the dose 10 mg 2 times daily and 10 mg 3 times daily, respectively). The reference group consisted of 32 high-risk patients who did not receive didrogesterone for preventive or therapeutic purposes. It was shown that in women with a history of habitual miscarriage administration of didrogesterone is pathogenetically justified at the stages of pregravid preparation, implantation and anatomic-functional formation of the placenta to prevent spontaneous abortion and undeveloping pregnancy that are responsible for a high incidence of reproductive losses. The use of didrogesterone at the stage of pregravid preparation and in early pregnancy permits to decrease the occurrence of threatened abortion by 2.3 times, to prevent detachment of chorionic tissue and extraembryonic membranes, and spontaneous abortion. For evaluation of the effect of administered prophylaxis and therapy of threatened abortion not only clinical and laboratory examination is important but also instrumental examination with biofetometry and dopplerometry.