Gynecology, Obstetrics and Perinatology

Immunological aspects of autoimmune thyroiditis and magnesium deficiency in women of reproductive age on the background of hormonal contraception

At present, studying the effect of hormonal contraception on the immune status of women with autoimmune thyroiditis and on the level of magnesium, one of the most vital trace elements in the human body, is very topical. The objective: to study the level of T helper cells, cytotoxic T lymphocytes, T killers, NK, B cells, thyroglobulin antibodies (TgAb), thyroid peroxidase antibodies (TPOAb), level of magnesium in blood in women of reproductive age with autoimmune thyroiditis (AIT) before and in the presence  of  therapy  with  the  contraceptive  ethynil  estradiol+desogestrel  (Regulon).  Results  of  the  study:  the  immune  status  in women with AIT is characterized by a high level of T helper cells, a low level of cytotoxic T lymphocytes, a high level of T killers and relatively normal values of NK and B cells. Detection of the magnesium level in blood showed its moderate deficiency in most women. On the background of intake of ethynil estradiol+desogestrel a decrease of the levels of T killers and thyroid antibodies was observed, in particular, TPOAb, which might decrease their toxic effect on the thyroid gland, and the level of magnesium in blood also tended to decrease. Conclusion: low-dose hormonal contraception has a positive effect on the course of AIT, but aggravates magnesium deficiency in blood in such women, and in this connection we consider it expedient to administer the drug Magne-B6 on the background of contraception.