Gynecology, Obstetrics and Perinatology

The etiology and pathogenesis of premature rupture of membranes in incomplete abortion

A review of modern literature deals with specific factors of etiology and pathogenesis of one of the most topical problem of perinatology – premature rupture of membranes (PROM) in incomplete abortion. Current evidence of the role of an increased activity of matrix metalloproteinases (MMPs) in amniotic fluid in the genesis of PROM is presented. Among many factors involved in pathological processes in PROM the most significant are microbial invasion of the amniotic cavity, activity of oxygen radicals (oxidant stress) and cell apoptosis that are possible causes of activation of PROM and degradation of membranes.