Gynecology, Obstetrics and Perinatology

An evaluation of the cytokine levels in pregnant women with viral infection

A comparative analysis of cytokine levels in blood serum (IL-12, IFN, TNF), in culture of mononuclear cells of peripheral blood (IL-12,  TNF),  in  amniotic  fluid  (IL-1?, IL-12, IFN-?, IL-4) of healthy pregnant women and pregnant women with viral infection detected  a  considerable  increase  of  IL-12  in  blood  serum  and  its  spontaneous  production  by  mononuclear  cells  in  pregnant women with viral infection. In pregnant women with viral infection, in 100% of cases IFN-? was not detected in either blood serum or amniotic fluid. In serum of healthy pregnant women TNF-? practically was practically not detected, whereas in pregnant women with urogenital infections of viral genesis, the concentration of TNF-? reliably increased by several times and was 125 ± 20 pg/ml. Production of TNF-? by mononuclear cells of peripheral blood in patients with urogenital infections increased 2-fold as compared to the control group. The IL-1? content in amniotic fluid (AF) in healthy pregnant women was by 2.4 times lower than in women with UGI of viral etiology, and content of the anti-inflammatory cytokine IL-4 by 4.3 times was higher in AF of patients with UGI as compared to healthy parturient women.