Gynecology, Obstetrics and Perinatology

Hormonal regulation and apoptotic factors in glandular cells of a normal and pathological endometrium

The articles presents the results of expression of pro- (BAX, P53), antiapoptotic (BCL-2) factors and the estrogen and progesterone receptors in the endometrium. In a normal proliferative and hyperplastic endometrium without atypia more than 90% of glandular cells contain receptors for steroid hormones, in a malignant transformation one can observe a proliferation of atypical  glandular  cells  with  a  low  content  of  receptors  for  estrogens  and  progesterone.  An  evaluation  of  the  sensitivity  of  the endometrium to steroid hormones of the glandular component in neoplastic processes has significant implications for administration of steroid therapy. The Prof.53 factor is a marker of anaplastic changes in the endometrium. This sign can be used in a differential diagnosis of atypical hyperplasia and highly differentiated adenocarcinoma of the endometrium. Expression of receptors for estrogen and progesterone, for the BCL-2 and P53 proteins serve as prognostic markers in anaplastic processes in the endometrium. A high concentration of the Prof.53 protein, absence of expression of BCL-2 or the estrogen and progesterone receptors is characteristic of a worse prognosis for the course of disease.