Clinical Practice in Pediatrics

Glycyrrhizic acid for the treatment of atopic dermatitis

This article discusses the use of different licorice root components (glycyrrhizic acid and 18β-glycyrrhetinic acid) for the treatment of atopic dermatitis. We describe the mechanisms of their action as well as therapeutic effects, including antiinflammatory, anti-allergic, and antibacterial effects. Particular attention is paid to the history of discovery of licorice active components, role of Russian scientists in studying glycyrrhizic acid and developing topical medications for patients with skin disorders, side effects of glycyrrhizin overdose, and future of glycyrrhizic acid.

Key words: atopic dermatitis, licorice, glycyrrhizin, glycyrrhizic acid, glycyrrhetinic acid, ammonium glycyrrhizinate.

For citation: Kudryavtseva A.V., Chebysheva S.N. Glycyrrhizic acid for the treatment of atopic dermatitis. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2019; 14(1): 57–62. (In Russian).
DOI: 10.20953/1817-7646-2019-1-57-62